When two light beams cross each other, neither of the beams is affected by the presence of the other. This fundamental property of light is often very convenient, for example when observing light which traveled large distances like the emission of distant stars. However, it is believed that novel computing and sensing technologies could greatly benefit from light-light interaction. These devices can potentially outperform their conventional counterparts by exploiting quantum mechanical properties when the light-light interaction is strong enough that an individual light particle, aka photon, significantly affects another one, for example by changing the propagation direction of the second photon. The trick to make photons interact is to send them through a medium which is extremely light sensitive. In our work we show that a single atom can act as such a medium. To couple the photons to the atom, we adapt a focusing configuration which is well-known from high- resolution imaging called 4Pi microscopy. In this configuration the light impinges onto the atom from two opposing directions. Our main results are the observations of a large photon-atom scattering probability, and of a change of the photon statistics induced by the atom. The latter is a signature of effective photon- photon interaction. With some technical improvements, the results from our proof-of-concept experiment can lead to a strong interaction between photons.